|Date of Birth||1971|
|Date of Death||N/a|
|Relative(s)||Brother: Sebastian Cross|
- "She always liked you better!"
- ―Brian Cross to Sebastian Cross
Brian is the older brother of Sebastian Cross.
- "You're a waste of good DNA!"
- ―Brian Cross
Brian Cross is cunning and spiteful personality. He resents his brother for reasons never fully explained. Brian has a soft spot for plants, in particular the Venus fly trap. Before the Raccoon City outbreak, he was of friend of Annette Birkin and Morpheus D. Duval.
Brian is known for his choice of fashion. He is usually dressed in a purple suit with a black and avacardo green shirt, white shoes and black gloves.
- Dual laser-sight Lightning Hawk (L. Hawk) magnum
- Double edged combat knife
He also has a small poison dart gun hidden up his left sleeve.
In his possession, Brian has copies of the Progenitor virus and flower, T-virus, G-virus, TG-virus, T Veronica virus and the last remaining NE-Alpha parasites. In addition to all that, he also has all the necessary data on all B.O.W.S found in the Arklay mountains, Rockford island and the Antarctica base.